Combination of two new drugs reverses lupus in mice

Combination-of-two-new-drugs-reverses-lupus-in-mice

[image credit: healthline.com]

New lupus drugs take years to develop, and may be ineffective

Lupus is a chronic autoimmune disease that can damage any part of the body, from the skin, to the joints, to the organs.

There is no cure for lupus, a disease that flares up and then seems to disappear before returning again.

About 1.5 million people in the United States, and 5 million people worldwide, live with the disease, according to the Lupus Foundation of America. About 16,000 new cases are diagnosed each year in the United States.

Solution: Explore combinations of existing drugs

Researchers said early last year they discovered that by using a combination of two drugs that already exist, it was possible to reverse the effects of lupus in mice.

The most surprising result from this study was that the combination of the two metabolic inhibitors was necessary to reverse disease.
Laurence Morel, Ph.D., University of Florida College of Medicine
In the February 2015 study published in Science Translational Medicine, researchers from the University of Florida, Gainesville, found that by inhibiting certain metabolic pathways in immune cells it was possible to combat lupus in mice.

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Article by: Dave

Dave Cannon is a Seattle-based entrepreneur and consultant to nonprofits and small businesses. He loves Thai food and takes terrible photographs. You can follow him on Linkedin.
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